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Most mammals encounter frequent and prolonged bouts of fasting. Intricate mechanisms evolved to maintain homeostasis during fasting. The liver plays a central role in the response to fasting by producing fuels to supply the energetic needs of the body. Hepatocytes produce glucose and ketone bodies that are secreted to circulation to supply extra-hepatic tissues during fasting. Our lab investigates how chromatin and transcription factors regulate the fasting response.


Using genomic, metabolic and molecular biology approaches, we study the gene regulatory networks that mediate the liver’s response to fasting. We aim to better understand these transcriptional networks and how their dysregulation can contribute to obesity, diabetes and non alcoholic fatty liver disease (NAFLD).

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From Korenfeld et al., 2021 Cell Mol Gastroenterol Hepatol (CMGH). PMID: 33957303

ketogenic diet

Refeeding following fasting

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The re-introduction of food after a fasting period is characterized by a complex transcriptional response driving hepatic synthesis of fatty acids, triglycerides and cholesterol. We study the crosstalk between transcription factors, chromatin dynamics and enhancer activity  in the refeeding phase


Iron Homeostasis

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We adopt an unbiased approach to explore hepatic gene and chromatin regulation as mediators of iron homeostasis maintenance.

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Transcription Factor Cooperation

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From Goldberg et al., 2022 Nucleic Acids Res. PMID: 35556130 

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