Fasting Metabolism and Gene Regulation

Our lab investigates the response to fasting and how mammals adapt to recurrent and frequent bouts of fasting. We study the metabolically-beneficial aspects of fasting and search for ways to harness them to promote health.

Using genomic, metabolic and molecular biology approaches, we study the gene regulatory networks that mediate the liver’s response to fasting. We aim to better understand these transcriptional networks and how their dysregulation can contribute to obesity, diabetes and non alcoholic fatty liver disease (NAFLD).